Antifertility effects of mangosteen peel extract (Garcinia Mangostana L) on the amount, diameter and layer thickness of the Teka Folikel De Graaf
Hairani, Melyana Nurul Widyawati
Background: Mangosteen peel extract is a drug that has been widely consumed with various products and various dosage forms by many women because it has been believed to have benefits that can cure various diseases. The study of the administration of ethanol extract of papaya seeds can reduce the number of tertiary follicles and de follicles in which the ethanol extract of papaya seeds has some of the same compounds with mangosteen peel extract but there is no study of mangosteen peel extract against female reproductive folliculogenesis processes. The final process of folliculogenesis is producing de graaf follicles where de graaf follicles play an important role in the pregnancy process. Objective: To determine the effect of mangosteen peel extract on the number, diameter and thickness of de graaf theca follicular layer in female mice. Methods: Experimental studies with post-test only with control group design were carried out in 20 female mice which were divided into 4 groups. Giving mangosteen peel extract for 21 days. Data analysis using ANOVA and continued with post hoc multiple comparisons. Results: There was no difference in the number and thickness of the deafra follicle theca layer between the treatment groups and there was a difference in the mean diameter of de graaf follicles with a p value of 0.002 (p?0.05) after the administration of mangosteen peel extract. Conclusion: Mangosteen peel extract did not affect the amount and thickness of the theca follicle de graaf layer but had an influence on de graaf follicle diameter in female mice.