Vol. 4, Issue 4 (2019)
The effect of Moringa oleifera leaves nanoparticles extract on hematology profile in breast cancer patients of chemotherapy programs
Author(s): Nismawardah, Suharyo Hadisaputro, Rr. Sri Endang Pujiastuti
Breast cancer is a leading cause of cancer deaths in women (15.0%). One of the problems in breast cancer patients during chemotherapy was the risk of infection and 86.3% had anemia. This occurs because excessive free radicals are formed due to chemotherapy which are toxic and cause oxidative stress resulting in disturbances and decreased hematological profiles. Herbal plants that have been shown to have good activity in the human hematology system and as a source of antioxidants are Moringa Oleifera plants.
Method: True Research Experiments with single blind and pre-test-post test with control group designs. Sampling by simple random sampling was used to get 40 respondents divided into two groups. The intervention group was given treatment of extracts of Moringa Oliefera leaf doses of 28.57 mg / kg BW / day and antianemia while the control group was given antianemia alone for 21 days. Result: Tests between groups showed p value <0.05 which means that there was a significant effect after administration of Moringa Oleifera leaf extract to increase hemoglobin levels, hematocrit levels and the number of erythrocytes of breast cancer patients undergoing chemotherapy programs while the number of leukocytes only increase but not significant. This change is caused by the content of Moringa leaves such as iron, folic acid, B12, Vitamin C and flavonoids which trigger an increase in hematological profile and Moringa leaf extract in the form of 0.208μm nanoparticles increasing the absorption of the content. Conclusion: The Moringa leaf nanoparticles extract significantly increases hematological profile in breast cancer patients can be made one of the supporting therapies that support the improvement of patient's health during chemotherapy.